Application of Phase-Transfer Catalysis in the Synthesis of Esters of Some Spasmolytically Active Gamapiperaziny Proponols

Authors

  • P.O Osadebe

DOI:

https://doi.org/10.4314/just.v13i1.1016

Keywords:

Gamma-piperazinyl alcohols, spasmolytic activity, phase-transfer catalyzed (PTC), esterification procedures, solid-liquid PTC conditions

Abstract

The principles of phase-transfer catalysis was applied for the synthesis of some Gamma-piperazinyl propanols of general formula 1, which were synthesized for the purpose of studying the influence of esterification on their spasmolytic activity. It was found out that, esters of this type can be obtained in very good yields, utilizing the solid-liquid phase-transfer catalyzed (PTC) conditions and not the liquid-liquid PTC conditions. The method and conditions for their successful syntheses are described in this paper.

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Published

2016-01-18

Issue

Vol. 13 No. 1 (1993)

Section

Articles

License

JUST Vol. 43 Number 1 (2025) Copyright and Licensing statement

How to Cite

Application of Phase-Transfer Catalysis in the Synthesis of Esters of Some Spasmolytically Active Gamapiperaziny Proponols . (2016). Journal of Science and Technology, 13(1). https://doi.org/10.4314/just.v13i1.1016