RP-LC Determination of Ascorbic Acid, Paracetamol and Caffeine in Multicomponent Anti-Cold Preparation

Abstract

An RP-LC method for the simultaneous determination of ascorbic acid paracetamol and caffeine in a tablet matrix is described. The mobile phase was a mixture of methanol-NaH, (17:83 pH 4.25 ±0.03) and stationary phase Aquapore RP-300. Total chromatographic time was approximately 8 minutes and the method found to be cost effective. The method was used to analyze some brands of multi-component anti cold preparations on the local market Results were validated using the standard UV spectrophotometric methods for the assay of the individual components of these drugs.